Tissue destruction in arthritis: Experimental studies
نویسندگان
چکیده
.................................................................................................................... 9 Introduction..............................................................................................................11 Rheumatology ...................................................................................................................... 11 Arthritis.....................................................................................................................12 Rheumatoid arthritis............................................................................................................. 12 Experimental models............................................................................................................ 14 The normal joint.......................................................................................................15 The inflamed joint ................................................................................................................ 16 Articular cartilage................................................................................................................. 17 Bone ..................................................................................................................................... 19 Molecular markers...................................................................................................19 Cartilage markers ................................................................................................................. 19 Bone markers........................................................................................................................ 21 Synovial markers.................................................................................................................. 22 Inflammation markers .......................................................................................................... 23 Anti-rheumatic treatment ........................................................................................25 Corticosteroids ..................................................................................................................... 26 CNI-1493.............................................................................................................................. 27 Aims of this thesis...................................................................................................28 Papers included in this thesis ................................................................................29 Paper I .................................................................................................................................. 29 Paper II ................................................................................................................................. 29 Paper III................................................................................................................................ 31 Paper IV................................................................................................................................ 32 Discussion and conclusions ..................................................................................32 Acknowledgements.................................................................................................35 References ...............................................................................................................37
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